Below is a step-by-step guide which you may find helpful when demonstrating how to use Fyremadel® with your patients. You can also direct your patients to these instructions on the Fyremadel® patient area of this website, which you can access here.
How to inject Fyremadel using the pre-filled syringes.
Fyremadel is supplied in pre-filled syringes that contain one dose. You should only use a Fyremadel pre-filled syringe once, after which it should be disposed of by placing into a Sharps Container.
Wash your hands thoroughly with soap and water.
The contents of the pre-filled syringe should be injected slowly, just under the skin (subcutaneous), preferably in the upper leg.
There are several other sites on the body where the injection can be administered. A subcutaneous injection may be administered in certain areas of the abdomen, thigh, upper arm and lower back/buttocks. It is very important to rotate injection sites, as this keeps the skin healthy and enables a better absorption of the drug.
Each time you inject yourself, it is recommended that you select a different injection site to the previous site used. For detailed injection technique in all eligible body sites, you are advised to contact the prescribing physician.
Swab the injection site with a disinfectant (for example alcohol) to remove any surface bacteria.
Clean about 5cm (two inches) around the point where the needle will go in and let the disinfectant dry for at least one minute before proceeding.
Inspect the solution before use. Do not use if the solution contains particles or is not clear. Do not mix Fyremadel with any other medicines.
Remove the needle cover.
Pinch a large area of skin between finger and thumb.
Insert the needle at the base of the pinched-up skin at an angle of 45° to the skin’s surface. For a subcutaneous injection, the whole needle should be inserted into the skin.
To check the needle is in the correct position, gently draw back the plunger. If any blood appears, the needle tip has penetrated a blood vessel.
If this happens, do not continue with the injection of Fyremadel. Remove the syringe, cover the injection site with a swab containing disinfectant and apply pressure; bleeding should stop in a minute or two.
You must also dispose of the syringe and start again with a new one.
Once the needle is correctly positioned, depress the plunger slowly and steadily, so the solution is correctly injected.
Once the plunger is fully depressed and all the drug has been injected, pull the syringe out quickly and apply pressure to the site with a disinfectant swab.
Remind patients to report any side effects they may experience to their fertility clinic or pharmacist. This includes any possible side effects not listed in the package leaflets. Patients can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard.
By reporting side effects patients can help provide more information on the safety of these medicines.
UK-RMMH-2000016 Date of preparation: May 2020