Here you will find answers to some of the questions your patients may ask you about Fyremadel®. You can also direct your patients to these instructions in the Fyremadel® patient area of this website, which you can access here.
What is Fyremadel?
Fyremadel is a hormone treatment that suppresses your body’s naturally-occurring egg-producing hormones.
What does Fyremadel do?
If your natural hormones are allowed to do their job, a single egg will mature and release each month. Fyremadel controls these hormones to suppress release. Meanwhile, your doctor will give you a follicle stimulating hormone (FSH) which will make multiple eggs mature at the same time. These unreleased, mature eggs are then ready to be harvested for IVF and similar treatments.
When should you not use Fyremadel?
You should not use Fyremadel if you are: allergic to any of its ingredients such as ganirelix (or other excipients listed in the patient information leaflet); hypersensitive to gonadotrophin releasing hormones; pregnant or breast feeding or have moderate or severe kidney or liver disease. Fyremadel treatment is not advised in women with severe allergic conditions. You should not use Fyremadel if you have a latex allergy as the needle cover contains dry natural rubber/latex which comes into contact with the needle and may cause allergic reactions.
Can I take any other medicines while using Fyremadel?
Please consult with your doctor if you are taking, have recently taken or might take any other medicines to make sure the combination is safe.
Does Fyremadel contain sodium?
Fyremadel is essentially sodium free, containing less than 1mmol sodium (23mg) per injection.
How do I use Fyremadel?
You must inject yourself with the pre-filled Fyremadel syringes; your doctor will show you how and when to use it. For more detailed information on how to inject, take a look at our How To Use guide here.
What should I do if I take too much Fyremadel?
You should contact your doctor if you take too much Fyremadel.
What should I do if I forget to take my Fyremadel?
When you realise you have forgotten, administer a dose as soon as possible. Do not give yourself a double dose to make up for the missed dose. If you are more than six hours late (and it has therefore been more than 30 hours since your last dose), administer the injection and then contact your doctor for further advice.
What are the side effects of Fyremadel?
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Common: You may have temporary redness or swelling around the injection site.
Uncommon: Some people generally feel unwell or experience headaches or, nausea.
Very rarely, people may have an allergic reaction to the medicine including rash, facial swelling, difficulty with breathing and/or swallowing (anaphylaxis) or worsening of a pre-existing eczema.
You should also be aware the follicle stimulating hormone (FSH) that is taken in conjunction with Fyremadel can cause some other serious side effects. Among them is Ovarian Hyperstimulation Syndrome (OHSS) where your ovaries overreact to the fertility medicine you are taking and can cause abdominal swelling, bloating, abdominal pain, nausea, vomiting, diarrhoea or shortness of breath.
Should I be worried about Ovarian Hyperstimulation Syndrome (OHSS) while taking Fyremadel?
Fyremadel does not cause OHSS.
However, you should be aware that the follicle-stimulation hormone (FSH) that is taken in conjunction with Fyremadel can cause OHSS, where your ovaries overreact to the stimulation. Mild OHSS is very common, occurring in about one in three women who receive ovarian stimulating hormones. It can cause abdominal swelling, bloating, abdominal pain, nausea, vomiting, diarrhoea or shortness of breath. In more severe cases it can cause dehydration, low blood pressure, blood clots or even death.
If you suspect you are suffering from these symptoms, please immediately consult with your doctor who may recommend temporarily stopping your fertility treatment.
Does using Fyremadel put my pregnancy at risk?
There are some risks related to the controlled ovarian stimulation treatment for ART. There is more chance of a multiple pregnancy (twins or more) which means there are more health risks for the mother during pregnancy and birth. There is more chance of an ectopic pregnancy (where a fertilised egg implants outside the womb). There is a greater risk of miscarriage and there may also be a slightly higher risk of your baby being born with physical defects.
UK-RMMH-2000016 Date of preparation: May 2020